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Description

Pep4 is a selected fragment of SLPI (Secretory Leucocyte Protease Inhibitor), whereas Pep4M is a modified form in which the highly reactive cysteine residues were replaced with less reactive methionine residues

PLoS Negl Trop Dis 13:e0007186

The shared pathological mechanisms discussed below are graphically summarized in Figure 1, and the corresponding molecular targets and druggable nodes are illustrated in Figure 2

Zhou J, Yang Y, Xie Z, Lu D, Huang J, Lan L et al (2024) Dysbiosis of gut microbiota and metabolites during AIDS: implications for CD4 + T cell reduction and immune activation